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KMID : 0370219830270040257
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Yakhak Hoeji
1983 Volume.27 No. 4 p.257 ~ p.261
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Drug-Biomacromolecule Interaction (VI) Binding of Nalidixic Acid and Probenecid to Bovine Serum Albumin
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김종국/Kim CK
임연수/양지선/Lim YS/Yang JS
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Abstract
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Binding of nalidixic acid which is used primarily in the treatment of urinary infection and probenecid which is used as a uricosuric agent to bovine serum albumin were studied using difference spectrophotometric method. 2-(4’’-Hydroxybenzeneazo) benzoic acid as a .spectrophotometric probe was used for measuring the binding of nalidixic acid and probenecid to bovine serum albumin. The association constants of nalidixic acid and probenecid were 1.58 X 104 M-1 and 1.70 X 104 M-1, respectively
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